| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2003-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f947f4c8e9fb621707789d091e6271c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35ed0bf1f4b0db8ec99b9e15aadd7e76 |
| publicationDate |
2004-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004180811-A1 |
| titleOfInvention |
Compositions involving M-RIP, and related methods for screening for anti-hypertensive agents, and uses thereof |
| abstract |
The present invention relates to screening methods that make use of Myosin Phosphatase-Rho interacting Protein (M-RIP) for the identification of novel therapeutics for hypertension and hypertensive conditions. Also disclosed are methods for treating or preventing hypertension or hypertensive conditions by administering to a mammal a therapeutically effective amount of an agent that reduces the level or activity of M-RIP. According to this invention, the agent decreases contractile and increases relaxant effects of smooth muscle cells, ultimately decreasing the systemic blood pressure of a mammal. For example, the agent may reduce binding of M-RIP to myosin phosphatase, RhoA, or both. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2890815-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015038857-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10697015-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011032223-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012304940-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9181585-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015218652-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2010295245-B2 |
| priorityDate |
2002-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |