| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3155f0c2660bc45fd48cf1ca0fee8fc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A90-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
| filingDate |
2003-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45660d57c180c245c9becab72e15ba95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_defa85cd1698b73b3f697a1d2adaefde |
| publicationDate |
2004-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004176912-A1 |
| titleOfInvention |
Methods for designing specific inhibitors for Pin1 proline isomerase and Pin1-related molecules |
| abstract |
This invention relates to methods for designing specific inhbitors of Pin1/parvulin family of peptidyl-prolyl cis-trans isomerases, particularly Pin1 and Pin1-related proteins, through the use of the structure coordinates and atomic details elucidated from the crystal structures of a mutant of Pin1, R14A, and co-complexes of R14A with various inhibitors. The invention further relates to inhibitors of Pin1 and Pin1-related proteins that are useful for therapeutic treatement of various disorders, and methods of using Pin1 inhibitors in pharmaceutical compositions. The invention further relates to the crystal structures of Pin1R14A alone, and of Pin1R14A in co-complex with molecules that bind to Pin1. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10265288-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10485780-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548864-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10413548-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9730941-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11129835-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012125724-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9968579-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10351914-B2 |
| priorityDate |
2002-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |