abstract |
A pharmaceutical composition for alleviating tissue hypoxia, comprising n (1) α-globin having the Titusville mutation, n (2) a polynucleotide comprising a base sequence encoding an amino acid sequence of the α-globin having the Titusville mutation, or n (3) an expression vector comprising the polynucleotide, and a pharmaceutically acceptable carrier or diluent, is disclosed. n Further, a method for alleviating tissue hypoxia comprising administering the same to a subject, and a transgenic non-human animal having expressably a polynucleotide comprising a base sequence encoding an amino acid sequence of α-globin having the Titusville mutation, are disclosed. |