| abstract |
The invention relates to compounds that are selective inhibitors of matrix metalloproteinases, to pharmaceutical compositions containing them and to their use in the prevention and/or treatment of MMP-associated diseases. The invention also relates to methods for identification of lead compounds that are selective inhibitors of matrix metalloproteinases. The compounds have the properties that they: n (a) bind allosterically to a matrix metalloproteinase or small group of metallic metalloproteinases; n (b) bind into at least the S1′ pocket, at least the S1″ pocket (as defined) or at least the S1′ pocket and the S1″ pocket of said matrix metalloproteinase; and n (c) exhibit selectivity for a matrix metalloproteinase or group of matrix metalloproteinases other than MMP-13. |