http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004166161-A1

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filingDate 2002-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e2d3bc8d37f47ce740b13397fd7d2c2
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publicationDate 2004-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2004166161-A1
titleOfInvention Pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance and respective processes of producing same and a cup-shaped envelope of same
abstract A tablet system for prolonged floating in or on gastric fluid for releasing therein pharmaceutically active substances in an alternate succession of substance release and no-release periods is made up of a multilayered core placed in a cup-shaped envelope. The core is made up of release layers and no-release layers devoid of pharmaceutically active substance, superposed in alternate succession. The cup-shaped envelope covers bottom and side surfaces of the core while leaving exposed an upper surface of the core. The cup-shaped envelope provides for buoyancy by being formed of a compression-sintered mixture comprising hydrophobic material and inert powdered filler. The hydrophobic material is composed of fatty and/or waxy material capable of being sintered by compression and whose bulk density is lower than gastric fluid density. The powdered filler has a loose powder density that is lower than gastric fluid density.
priorityDate 2001-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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