| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
| filingDate |
2003-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84b78e58e7818efd053c37f5766326d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c21cddadd0f7e96d7e20fc1b4f5192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1a5917e562a98c41ae15be7162802a3 |
| publicationDate |
2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004158070-A1 |
| titleOfInvention |
Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
| abstract |
A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (Donepezil HCl) is disclosed. 5,6-Dimethoxy-2-(pyridin-4-yl) methylene inda-1-one is hydrogenated with a noble metal catalyst or a non-oxide derivative of a noble metal catalyst in a solvent at 20-100° C. and 10-90 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine is alkylated with an alkylating agent in an organic solvent at 20-80° C. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8124783-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009118516-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8247563-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008153878-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007043440-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8580822-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009137812-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102367236-A |
| priorityDate |
2003-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |