http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004158061-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-12 |
| filingDate | 2002-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56bd6669bb3b5ed9c833c8377f25a580 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc677ef3e130022d6cf16d3b44dbedc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c94dcd338fd516ef7c00a780ebfb173 |
| publicationDate | 2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004158061-A1 |
| titleOfInvention | Reaction of (di)amines in the presence of a lysine oxidase and of a reducing agent |
| abstract | The present invention relates to a method for reacting amines of the general formula (I) n n n with A- meaning n n n to give compounds of the general formula (II) or (III) n n n with B- meaning HO—CH 2 —R 3 — or R 4 — n comprising the following steps: n a) oxidation of at least one n n n group of an amine of the general formula (I) to a carbonyl group in the presence of a lysine oxidase as catalyst; n b) where appropriate reaction of the second NH 2 group of an amine of the general formula (I) with n n n with the carbonyl group resulting from a) to give an enamine or imine by cyclization; n c) reduction of the carbonyl group(s) resulting from a), or of the enamine or imine resulting where appropriate from b), with a reducing agent respectively to hydroxymethyl groups or to a cyclic secondary amine of the general formula (II), n where R 1 is NR 5 or a linear bivalent C 2 -C 6 hydrocarbon radical which is optionally substituted by CO 2 H, CO 2 R 6 , OH, SH and/or N(R 5 ) 2 and/or contains nonadjacent O, S and/or N atoms, n where R 5 is H or linear C 1 -C 6 -alkyl and R 6 is linear Cl-C 6 -alkyl or branched C 3 -C 6 -alkyl or C 6 -C 10 -aryl, n and R 2 is H, CO 2 H, CO 2 R 6 or CN, n where the method is carried out as a one-pot method, lysine oxidase and reducing agent are present together, and n in the definition of A in the general formula (I) n R 3 is a bivalent C 0 -C 1 or C 5 -C 18 hydrocarbon radical which is optionally substituted by linear C 1 -C 6 -alkyl or branched C 3 -C 6 -alkyl, C 6 -C 10 -aryl, C 4 -C 10 -heteroaryl and/or CO 2 R 6 and/or contains nonadjacent O, S and/or N atoms, and n R 4 is a linear C 1 -C 20 hydrocarbon radical which is optionally substituted by functional groups such as CO 2 H and/or C0 2 R 6 and/or contains nonadjacent O, S and/or N atoms. |
| priorityDate | 2001-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.