http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004157918-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 |
| filingDate | 2001-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dfd8750392d22d56214958a8ccb0909 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_527b7075f5b0ae14cb79e638933c01fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d8f2790736abf8bd2187e22fddca693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbf60d586710c09076b2ba0040749fe1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f6473c766a64daf6406ee563d925135 |
| publicationDate | 2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004157918-A1 |
| titleOfInvention | Weight loss induced by reduction in neuropeptide y level |
| abstract | This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted α-methylene-β-carboxyl-γ-butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7705016-B2 |
| priorityDate | 2001-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 687.