| abstract |
The present invention relates to new new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives compound having the formula (I) n n n wherein n X is N or CH; n Y is NR 2 CH 2 , CH 2 NR 2 , NR 2 CO, CONR 2 , NR 2 SO 2 or NR 2 CONR 2 n wherein R 2 is H or C 1 -C 6 alkyl; n R 1 is H, C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl; n R 3 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl or (CH 2 ) n -aryl, n wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted with R 4 and/or R 5 ; n and n is 0-4; n as (R)-enantiomers, (S)-enantiomers or a racemate in the form of a free base or a pharmaceutically acceptable salt or solvate thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds. |