| abstract |
Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: n {X—OOC—[(CH 2 ) n —COO] m } p —Y (I) n wherein: n X is a residue of a hydrophobic moiety, n Y is a residue of a hydrophilic moiety, n p is 1 or 2, n m is 0 or 1, and n n is an integer greater than or equal to 0 n are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is α-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18. |