| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10123
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5258
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55561
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-292
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02 |
| filingDate |
2003-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5b91374f0190e8ea176cf4be9b0f1ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b59a770de0b315d1156a8b1a22cc15f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7e546395ada764a6ff86fa918a79d9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fece7edfdd6df2cb15df71ded179532 |
| publicationDate |
2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004156863-A1 |
| titleOfInvention |
Stabilized HBc chimer particles as therapeutic vaccine for chronic hepatitis |
| abstract |
A method of treating chronic hepatitis B is disclosed that comprises administering a T cell-stimulating amount of a vaccine to a patient. The vaccine comprises an immunogenic amount of chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more of the N-terminus, the immunogenic loop or the C-terminus of HBc. The enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near one or both of the amino-terminus and carboxy-terminus of the chimer molecule. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9393299-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011015656-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BE-1021939-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7270821-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2672992-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9603921-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009087453-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004223965-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009074803-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10195268-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8883169-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014507146-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9403879-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004053091-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3760227-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014141127-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004106174-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8071561-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9827260-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10695421-B2 |
| priorityDate |
2002-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |