| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-148
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2535-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0671
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate |
2003-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d38ad547b07dca1c2d87b480a2ca6bb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e289af5572e2c9d8a6082054c620ea3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_773f178832221d123099a58994e5a4bf |
| publicationDate |
2004-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004152149-A1 |
| titleOfInvention |
Textiles for use in bioreactors for expansion and maintenance of cells |
| abstract |
A bioreactor for three-dimensional culture of liver cells is disclosed. The device is characterized by the use of textile vasculatures. A model and method for optimizing vasculature parameters is also disclosed. Liver acinar structure and physiological parameters are mimicked by sandwiching cells in the space between the two innermost woven textile hollow fibers, and creating radial flow of media from an outer compartment, through the cell mass compartment, and to an inner compartment. The theoretical optimum hydraulic permeability for the two innermost semi-permeable membranes is determined based on physiological hepatic sinusoidal blood flow and pressures. Experimental studies using a flow rate and pressure monitoring systems in conjunction with phase-contrast velocity-encoded MRI confirm theoretical results. Novel woven vascular tubes with optimum hydraulic permeability are disclosed for culturing hepatocytes in the multi-coaxial bioreactor. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008248572-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10053661-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9005550-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11612119-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011020923-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020056137-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020137970-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10155924-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017092389-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2008236529-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022005858-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003181970-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9976114-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113728085-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9790929-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7063721-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8778669-B2 |
| priorityDate |
2002-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |