http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004147743-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 |
| filingDate | 2002-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c138a66966f09d019cb53182b86faa1 |
| publicationDate | 2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004147743-A1 |
| titleOfInvention | Synthesis of branched acyclic nucleosides |
| abstract | A method for the preparation of acyclic nucleosides such as valomaciclovir stearate comprising the acid hydrolysis of an intermediate of the formula II: where X is a leaving group or an optionally protected guanine moiety, R1 is a hydroxy protecting group or a —C(═O)C1-C22 alkyl ester group; R2 and R3 are independently lower alkyl or benzyl, or R2 and R3 taken together are —CH2CH2— or —CH2CH2CH2— or —CH2CH2CH2CH2—; to the corresponding aldehyde of the formula III: and the reduction of the aldehyde to the corresponding alcohol of the formula IV: by the addition of a borohydride or borane aldehyde reducing agent, characterised in that the borohydride or borane aldehyde reducing agent is introduced under acid conditions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9492456-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010240681-A1 |
| priorityDate | 2001-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 231.