abstract |
A pharmaceutical composition comprising a compound of formula 1 n n n wherein: n n is 1 or 2; n R 1 is hydrogen, C 1 -C 4 -alkyl, halogen, OH, or —O—C 1 -C 4 -alkyl; n R 2 is hydrogen, C 1 -C 4 -alkyl, halogen, OH, or —O—C 1 -C 4 -alkyl; n R 3 is hydrogen, C 1 -C 4 -alkyl, OH, halogen, —O—C 1 -C 4 -alkyl, —O—C 1 -C 4 -alkylene-COOH, or —O—C 1 -C 4 -alkylene-CO—O—C 1 -C 4 -alkyl, or n an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and n a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD). |