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filingDate 2001-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2004147434-A1
titleOfInvention Use of enzyme inhibitors of the dipeptidypeptidase iv (ec3.3.14.5) in addition to the aminopeptidase n (ec 3.4.11.2), individually or in a combination thereof, and pharmaceutical preparations thereof for the prevention and/or therapy of ischaemia-caused acute and chronic neurodegenerative process and illnesses, for example
abstract The present invention relates to a process wherein, by a separate or simultaneous administration and effect of inhibitors of the enzymes alanyl aminopeptidase (APN) and dipeptidyl peptidase IV (DP IV) or of enzymes having the same or a similar substrate specifity, the damage of cerebral tissue as a consequence of an ischemia or a cranial/cerebral trauma can be reduced or prevented. n The invention shows that the separate or combined application of inhibitory substances of the above-mentioned enzymes or of corresponding preparations or administration forms is definitely suitable for a prevention and therapy of the above indications.
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