| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46c61b747b4b4033fa1d641f2d6012a5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-20022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-22022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2003-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5061372fbf9f21b3c79e27eb6e244cb4 |
| publicationDate |
2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004147006-A1 |
| titleOfInvention |
Peptides that bind to DNA and inhibit DNA replication, and methods of use |
| abstract |
Isolated peptides are provided that span the Simian Virus 40 DNA region of the T-ag (or the Bovine Papillomavirus E1 protein) centered on position Thr124 (or Thr102, respectively), which include regulatory motifs, such as the nuclear localization signal (NLS) and the consensus recognition site for cyclin-Cdk kinases. When unphosphorylated, peptides derived from this region bind to DNA and inhibit T-ag assembly. Upon phosphorylation at Thr124 (or Thr102), these peptides neither bind to DNA nor to inhibit T-ag assembly. These forms of regulation of DNA replication and T-ag assembly provide a novel target, and provide screens for anti-viral agents, and for gene therapy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006286574-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7455840-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009136518-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006111302-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110790823-A |
| priorityDate |
2001-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |