| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
2001-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9548ee924eb46f996e3697a7f89b3686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_479f34c68ce0824396c3447f9ee4f883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a317578d5bd2c7a138bdc7ab8a7eb2d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7299865c58830bbddf13cb08c787144
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25112ef62dc12e30bf164d6af5fba1de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_858dfac1acf8cad8db1bc4b136850d4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_172d74590621f05f2554b0e6b1d884a8 |
| publicationDate |
2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004146968-A1 |
| titleOfInvention |
Three dimensional structure of human derived apoptotic factor and receptor thereof x-ray crystallography and trail deletion mutant protein |
| abstract |
The present invention relates to a method for preparing the crystal of human derived TRAIL protein and TRAIL receptor protein sDR5 complex and the crystal of TRAIL-sDR5 complex prepared by the method. The present invention also TRAIL relates to a three-dimensional structure of TRAIL protein in the form of complex with TRAIL receptor sDR5 as well as TRAIL protein itself, and specific residues existed in the contact central region of AA″ loop. The three-dimensional structure of TRAIL-sDR5 complex and the specific residues in the AA″ loop of the present invention can be effectively used for not only the development of TRAIL protein having the better cytotoxic activity and having the improved receptor biding affinity, which specifically kills viral infected cells or cancer cells but also molecular strategy for regulating the binding specificity between TNF and TNFR family. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008044376-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7994281-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11007251-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299528-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111450232-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11084879-B2 |
| priorityDate |
2000-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |