| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-30 |
| filingDate |
2001-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bbc0cde369dc10977dbee4e384f2e6a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87b425eb025af91f8dc918564947876d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bcb2d85f9612378df996799e5819375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aa664e8f245762543e6c62377901306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f406ec144333b3083583acf73b419fe3 |
| publicationDate |
2004-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004143023-A1 |
| titleOfInvention |
Materials and methods for synthesizing stilbenes |
| abstract |
The present invention relates materials and methods for synthesizing stilbenes, and in particular to processes for the synthesis of substituted stilbenes such as combretastatin A4. The present invention relates in particular to methods which are stereoselective for either the cis or the trans isomer of the substituted stilbene, using a Perkin-type condensation of an arylacetic acid and a substituted benzaldehyde, followed by a decarboxylation reaction to produce the substituted cis-stilbenes or a Suzuki-type reaction involving a Z or E-ethenyl halide and a substituted boronic acid in the presence of a palladium catalyst to produce specifically either the Z or E-isomer of substituted stilbenes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013003112-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016094897-A1 |
| priorityDate |
2000-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |