| abstract |
A compound of the formula (I) n n n wherein n R 1 is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR 3 R 4 ; n R 2 is hydrogen; or aryl or heteroaryl, each of which may be substituted; n X is direct bond or bivalent residue derived from piperazine; n Y is -(A 1 ) n -(A 2 ) m -, wherein n and m are independently 0 or 1); n n n is bivalent residue derived from arene or heteroarene; and n n n is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B. |