http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004131574-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-785 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-133 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-13 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-133 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-84 |
| filingDate | 2002-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_986e49325b3e1562de50b991da744fd7 |
| publicationDate | 2004-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004131574-A1 |
| titleOfInvention | Method and composition for the control of hair growth |
| abstract | Disclosed are pharmaceutical compositions and methods for controlling the growth of hair by topically applying to a human or non-human mammal a polyamine or a salt thereof with a pharmaceutically acceptable acid, the polyamine having formula (I) wherein: R 1 -R 6 may be the same or different and are hydrogen, alkyl, hydrocarbyl aryl, hydrocarbyl aryl alkyl, cycloalkyl, or any of the foregoing wherein the alkyl chain is interrupted by at least one etheric oxygen atom with the proviso that R 1 and R 6 may not both be hydrogen; N 1 , N 2 , N 3 and N 4 are nitrogen atoms capable of protonation at physiological pHs; a and b may be the same or different and are integers from 0 to 6; A, B and C may be the same or different and are integers from 0 to 6; A, B and C may be the same or different and are bridging groups of variable length, including unsubstituted heterocyclic bridging groups which incorporate as a hetero atom therein said N 1 or N 4 ; and further wherein said A, B, C are selected such that they effectively maintain the distance between the nitrogen atoms such that the polyamine: (i) is capable of uptake by a target cell upon topical application of the polyamine to said human or non-human mammal; and (ii) upon uptake by the target cell, competitively binds via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell; the polyamine, upon binding to the biological counter-anion in the cell, functions to inhibit the formation therein of the enzyme, ornithine decarboxylase. |
| priorityDate | 2001-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 257.