http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004120961-A1
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-01 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-415 |
filingDate | 2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef3246fbf5b5757f5cda6722f6670b33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_112a72f471017f04d65424e0afd4f8b2 |
publicationDate | 2004-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2004120961-A1 |
titleOfInvention | Saposin C and receptors as targets for treatment of benign and malignant disorders |
abstract | Saposin C was shown to be a trophic factor for a variety of cancer cells, e.g., prostate, lung, breast, and colon cancer cells. These cells expressed saposin C and responded to saposin C by increased levels of cell proliferation, cell migration, and cell invasion. Such activities typify and promote the neoplastic process. For prostate cancer, the androgen-insensitive prostate cancer cells responded to saposin C by higher levels of cell proliferation, cell migration and cell invasion than did the androgen-sensitive prostate cells. Stromal cells (from the prostate) were also responsive to saposin C-mediated signals in a manner typical of growth promoting compounds. The androgen-insensitive prostate cells were stimulated by saposin C to express higher levels of the urokinase plasminogen activator (uPA) and its receptor (uPAR), two proteins known to be involved in cell invasion. A conjugate of a peptide of the active region of saposin C (TX14A) and a toxin (saporin) was made and was shown to decrease the survival of prostate cancer cells, and the other cancer cells that were found to express saposin C (including cancers cells of the breast, colon, and lung). This conjugate or a compound of analogous action that inhibits cellular growth acting via a saposin-C binding receptor can be used to decrease tumor growth and/or treat disorders of stromal proliferation (e.g., benign prostatic hyperplasia, atherosclerosis, and vascular restenosis). |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2365796-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012020878-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013096868-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10267799-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010144603-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2185204-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646541-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10670600-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10736935-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9921224-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11191805-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11654178-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11590196-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10175243-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7834147-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10188698-B2 |
priorityDate | 2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 588.