| abstract |
The invention relates to indole derivatives of formula (I) or (II) for use as inflammation modulators, especially having an inhibitory effect on protein kinases. Formula (I), wherein n=0 or 1, R 1 =R 2 =3-indole, R 3 ═COOH— or a ketone, X═O or NH; with the proviso that if n=0, R 4 ═OH and R 5 =3-indole; and if n=1, R 4 together with R 5 represents an indole ring system condensed to the structure in the 2,3 position and X═NH. Formula (II), wherein R 1 =R 2 =3-indole, X═O, CH 2 or a carbonyl group; X═O, a carbonyl group NH or >C═N(R′) 2 with R′═CH 3 or C 2 H 5 . The novel indole derivatives isolated from Melassezia are especially useful as substances for producing a medicament for the treatment of inflammatory or proliferative diseases, especially of the skin, but also of other organ systems. |