| abstract |
The invention concerns a novel galenic formulation of fenofibrate for oral administration and its method of preparation. The invention is characterised in that it consists of a tablet obtained by compressing a mixture comprising: a) a granular material containing: 1 to 5% of a surfactant, micronized fenofibrate, at least a solid support selected among starch, cellulose or their derivatives, except C 12 disaccharides; said granular material being obtained by granulating the mixture using an aqueous polyvinylpyrrolidone solution; b) crosslinked polyvinylpyrrolidone; c) optionally flow or lubricating agents, the amount of fenofibrate being more than 50 wt. %, expressed relative to the tablet weight. The invention is useful for treating hypercholesterolemia and hypertriglyceridemia. |