| abstract |
An excellent β secretase inhibitor is provided, which comprises a compound of the general formula: n n n wherein Ar is an aromatic group; X is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO 2 —, —NR 8 —, —CONR 8 —, —SO 2 NR 8 —, and —COO— (wherein R 8 is hydrogen, etc.), a divalent C 1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups, or a bond; Y is a divalent group selected from —O—, —S—, —CO—, —SO—, —SO 2 —, —NR 8 —, —CONR 8 —, —SO 2 NR 8 —, and —COO—, or a divalent C 1-6 aliphatic hydrocarbon group which may contain one or two of these divalent groups; R 1 and R 2 are hydrogen, a hydrocarbon group, etc., respectively; and A is a ring which may be further substituted, or a salt thereof. |