http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004106154-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0066 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 |
| filingDate | 2003-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09c359c3365d5da84562cef49483a193 |
| publicationDate | 2004-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004106154-A1 |
| titleOfInvention | In vivo screen using chemical inducers of dimerization |
| abstract | The subject invention provides a compound having the formula: n H1-X-B-Y-H2 n wherein each of H1 and H2 may be the same or different and capable of binding to a receptor which is the same or different; n wherein each of X and Y may be present or absent and if present, each may be the same or different spacer moiety; and wherein B is an enzyme cleavable moiety. This invention also provides a method of screening proteins for the ability to catalyze bond cleavage, comprising the steps of: n a) providing a cell that expresses a pair of fusion proteins which upon dimerization change a cellular readout; n b) providing the compound of the invention which dimerizes the pair of fusion proteins, said compound comprising two portions coupled by a bond that is cleavable by the protein to be screened; and n c) screening for the cellular readout, wherein a change the cellular readout indicates catalysis of bond cleavage by the protein to be screened. Finally, the invention also provides a method of screening proteins for the ability to catalyze bond formation, comprising the steps of: n a) providing a cell that expresses a pair of fusion proteins which upon dimerization activate a cellular readout: n b) providing a first compound and a second compound, each being capable of binding to one of the pair of fusion proteins, said first and second compound comprising a portion through which the first and second compounds are coupled to form the inventive compound by the action of the bond forming protein to be screened; and n c) screening for the cellular readout, wherein a change in the cellular readout indicates catalysis of bond formation by the protein to be screened. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010077470-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9169481-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011138778-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2535426-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8688427-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003138785-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009209038-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012100594-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010077470-A3 |
| priorityDate | 2000-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1489.