abstract |
Compounds of formula (I) in free or salt form, where Ar 1 is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C 1 -C 8 -alkyl optionally substituted by cyano or halogen, Ar 2 is phenyl optionally which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, C 1 -C 8 -alkoxy or C 1 -C 8 -alkoxycarbonyl, R 1 is C 1 -C 8 -alkyl substituted by hydroxy, C 1 -C 8 -alkoxy, acyloxy, —N(R 2 )R 3 , halogen, carboxy, C 1 -C 8 -alkoxycarbonyl, phenyl-C 1 -C 8 -alkoxycarbonyl, -CON(R 4 )R 5 or by a monovalent cyclic organic group, R 2 and R?3 are each independently hydrogen or C 1 -C 8 -alkyl, or R 2 is hydrogen and R 3 is acyl or SO 2 R 6 , or R 2 and R 3 together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R 4 and R 5 are each independently hydrogen, C 1 -C 8 -alkyl optionally substituted by hydroxy or phenyl, or phenyl optionally substituted by C 1 -C 8 -alkyl, halogen, cyano or C 1 -C 8 -alkoxy, or R 4 and R 5 together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R?6 is C 1 -C 8 -alkyl, C 1 -C 8 -haloalkyl, or phenyl optionally substituted by C 1 -C 8 -alkyl, and n is 1, 2, 3 or 4. The compounds are useful as pharmaceuticals. |