| abstract |
The invention relates to compounds of formula (I) n n n in which R 5 is chosen from the group consisting of: n n n in which R 2 is a C 1 -C 3 alkyl group n in which X may be Cl, Br, or F n in which n is between 1 and 3, in the E or Z form, or a mixture of the two isomeric forms, possessing antimitotic, antiproliferative and antivascular properties through inhibition of the polymerization of tubulin into microtubules. |