abstract |
A DNA, which encodes the following polypeptide (a), (b), (c) or (d): n (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2 or 4, n (b) a polypeptide consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 or 4 by deletion, substitution or addition of one or several amino acids, and having hypophosphatemia-inducing activity, phosphate transport-suppressing activity, calcification-suppressing activity or in vivo vitamin D metabolism-regulating activity, n (c) a polypeptide consisting of a partial sequence of the amino acid sequence represented by SEQ ID NO: 2, wherein the above partial sequence contains an amino acid sequence at least ranging from the 34 th to 201 st amino acids in the above amino acid sequence, or n (d) a polypeptide consisting of a partial sequence of the amino acid sequence represented by SEQ ID NO: 2, wherein the above partial sequence: n (i) contains an amino acid sequence ranging from at least the 34 th to 201 st amino acids in said amino acid sequence, n (ii) consists of an amino acid sequence derived from the partial sequence by deletion, substitution, or addition of one or several amino acids, and n (iii) has hypophosphatemia-inducing activity, phosphate transport-suppressing activity, calcification-suppressing activity or in vivo vitamin D metabolism-regulating activity. |