| abstract |
The invention provides isolated nucleic acids that encode MDZ3, MDZ4, MDZ7 and MDZ12, and fragments thereof, vectors for propagating and expressing MDZ3, MDZ4, MDZ7 and MDZ12 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel MDZ3, MDZ4, MDZ7 and MDZ12 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human MDZ3, MDZ4, MDZ7 and MDZ12 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human MDZ3, MDZ4, MDZ7 or MDZ12 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the MDZ3, MDZ4, MDZ7 or MDZ12 nucleic acids, proteins, and antibodies of the present invention. |