| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 |
| filingDate |
2003-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e834515f784ec62f711d8694fffcc37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a5249eea4b534d70a209c3349a20e2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c452fc1bd8ff6c00d9e8170515e6579
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8fb62d24822341cc453678370e4724d |
| publicationDate |
2004-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004077900-A1 |
| titleOfInvention |
Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-alpha, alpha-dimethylphenylacetic acid |
| abstract |
This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl) -α, α-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula 11 n n n is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007184133-A1 |
| priorityDate |
2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |