http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004077588-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 2003-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e716243e58fba1b672080793bf77cea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bc4c89d6053b42a2b91554f074a4dc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6e1ec8640618f9b12fd1abbcb10afb8 |
| publicationDate | 2004-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004077588-A1 |
| titleOfInvention | Enzyme catalyzed therapeutic compounds |
| abstract | This invention provides novel substrate compounds that selectively inhibit the proliferation f path logical cells, for example, pathological cells that endogenously overexpress a target enzyme that confers resistance to biologic and chemotherapeutic agents. The enzyme acts on a substrate compound to 1) convert it to a cellular toxin and/or 2) release a toxic byproduct. In one embodiment, the activity of the target enzyme has been greatly enhanced in a target cell as a result of loss f tum r suppressor function and/or selection resulting from previous exposure to chemotherapy. In another embodiment, the pathological cell contains a target enzyme that is an expression product of an infectious agent in the cell. Further provided by this invention is a method for treating a subject by delivering to the subject a prodrug as described herein. The prodrugs f this invention may be used alone or in combination with ther chemotherapeutics or alternative anti-cancer therapies such as radiation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10030044-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015081133-A3 |
| priorityDate | 1999-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1731.