http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004067904-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-0203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate | 2001-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94de29ec0c1c4c8cb6d825a7d3690d7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f401e3e3324e253359dc5abeaedc8a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c375eba2c9f16724018d9d6ed81ef1d4 |
| publicationDate | 2004-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004067904-A1 |
| titleOfInvention | Gene therapy for prostate cancer: sensibilization of cells to dna damaging drugs and radiation |
| abstract | The present invention is directed to a novel therapeutic method for treating prostate cancer. The method employs the tissue-specific PSA promoter/enhancer as well as the unique properties of the DNA binding domain (dbd) of poly (ADP-ribose) polymerase (PARP) as a potent inhibitor of DNA damage repair and as a molecular sensitizer to genotoxic stresses. The sustained presence of the PARP-DBD in prostate tumor tissue induces enhanced tumor cell killing in response to DNA damaging treatments. The invention may be used as a biotherapeutic approach in the treatment of prostate cancers, which fail local-regional therapy, without significant risk of normal tissue damage. |
| priorityDate | 2001-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 205.