abstract |
Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure n n n wherein m is 0, 1 or 2; n is 0, 1 or 2; n Q is C or N; n A is (CH 2 ) x where x is 1 to 5, or A is (CH 2 ) x 1 where x 1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is —(CH 2 ) x 2 —O—(CH 2 ) x 3 where x 2 is 0 to 5 and X 3 is 0 to 5, provided that at least one of x 2 and X 3 is other than 0; n B is a bond or is (CH 2 ) x 4 where X 4 is 1 to 5; n X is CH or N; n X 2 is C, N, O or S; n X 3 is C, N, O or S; n X 4 is C, N, O or S; n X 5 is C, N, O or S; n X 6 is C, N, O or S; n provided that at least one of X 2 , X 3 , X 4 X 5 and X 6 is N; and at least one of X 2 , X 3 , X 4 X 5 and X 6 is C, and specifically excluding the structure(s) as shown below: n n n where X 2 ═N, X 3 ═C, X 4 =O or S, Z=O or a bond n R 1 is H or alkyl; n R 2 is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; n R 2a , R 2b and R 2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R 3 and Y are as defined herein, which compounds are useful in treating diabetes and obesity. |