| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-327
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-416 |
| filingDate |
2003-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02dc83b69919e5f616060dcc4aa0dce7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12a36741048be7dacafd07da8843a1f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d37ad41dc4bbfa80976d4fd5b3b69f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a702b2a7147bd9c9d9e7915c3ffae483 |
| publicationDate |
2004-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004063126-A1 |
| titleOfInvention |
Electrochemical sensor using intercalative, redox-active moieties |
| abstract |
Compositions and methods for electrochemical detection and localization of genetic point mutations, common DNA lesions and other base-stacking perturbations within oligonucleotide duplexes adsorbed onto electrodes and their use in biosensing technologies are described. An intercalative, redox-active moiety (such as an intercalator or nucleic acid-binding protein) is adhered and/or crosslinked to immobilized DNA duplexes at different separations from an electrode and probed electrochemically in the presence or absence of a non-intercalative, redox-active moiety. Interruptions in DNA-mediated electron-transfer caused by base-stacking perturbations, such as mutations or binding of a protein to its recognition site are reflected in a difference in electrical current, charge and/or potential. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9429561-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012091005-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009036315-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9005425-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008026394-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906609-B1 |
| priorityDate |
1997-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |