| abstract |
According to this invention, there is provided an indole derivative having the general formula (I) n n n wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R 1 and R 2 each stand for a hydrogen atom or an alkyl group, independently, or (ii) R 1 and R 2 as taken together form a cycloalkyl group or an aromatic ring, or (iii) R 1 and R 2 as taken together form a heterocyclic ring, and R 3 is a hydrogen atom, a (C 1 -C 10 )alkyl group or others, R 4 is a substituted alkyl group and R 5 is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity. |