| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-944
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-94 |
| filingDate |
2001-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d46c5340c96835981f7ab8c41172b4ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d44cbbe20489712a2e3761c43631fbcc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5a6330f56b405b561ba9d19c6e656c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa917323ec9c1ed773ba78db77080a7d |
| publicationDate |
2004-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004058357-A1 |
| titleOfInvention |
System and method for assaying drugs |
| abstract |
The invention relates to a method and system for evaluating an effect on the nervous system of a test drug by comparing the effect of such drug on AChE catalytic activity or isoform variance in the brain of a test animal following challenge by an AChE blocker (e.g. DFP) or a blocker of AChE and muscarinic receptors M1 and M2 (e.g. pyridostigmine) and comparing this effect with that of a known agent, preferably a non-selective muscarinic receptor blocker (e.g. scopolamine) or a specific M1 receptor blocker (e.g. pirenzepine). Also provided is a method of screening for a candidate drug that is a modulator of the expression of any one of AChE variants and isoforms by determining the effect of such drug on the translocation of an AChE isoform within a neuron. Further provided is a method of screening for a candidate drug aimed at affecting central nervous system properties which is a modulator of the interaction between AChE-R/RACK1/PKC. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7931791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011139622-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9827250-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008149484-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8435396-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020081765-A1 |
| priorityDate |
2000-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |