| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate |
2003-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e2046ae54e611fb9bddc38e7fef1b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48c0d644d84bfe34ce664ce87d70402f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56fc85b55ba96b86ffeabb65182e2ca2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bf7f954cbcc273e1269b61802a7919f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de3660c65d2b6bd7beee883c6c9dd6d8 |
| publicationDate |
2004-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004055028-A1 |
| titleOfInvention |
Urocortin-deficient mice and uses thereof |
| abstract |
The present invention provides transgenic mice deficient in urocortin. Urocortin null mutant mice are hypersensitive to stress and display heightened anxiety-like behaviors in the elevated plus maze and open field tests. These mice also demonstrate physiological alterations in auditory thresholds and distortion product otoacoustic emissions. These results indicate that urocortin plays a modulatory role in anxiety-related behaviors and in contributing to the establishment of auditory thresholds. Such urocortin deficient mutant mice can provide useful models in the study of anxiety pathology and hearing physiology at the biochemical and molecular levels. |
| priorityDate |
2002-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |