| abstract |
The present invention is directed to polymeric-prodrug transport forms of the formula: n n n E 1-4 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy C 1-6 heteroalkoxy, n n n and at least one of E 1-4 includes a B moiety, wherein B is a leaving group, OH, a residue of a hydroxyl- or amino-containing moiety or n n n wherein J 1 is the same as J, or another member of the group defining J and E 5 is the same as E 1-4 , or another member of the group defining E 1-4 , n Y 1-2 are independently O, S or NR 9 ; n M is a heteroatom selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(═Y 2 ); n R 2-5 and R 7-9 are independently selected from the group consisting of hydrogen, C 1-6 alkyls, C 3-12 branched alkyls, C 3-8 cycloalkyls, C 1-6 substituted alkyls, C 3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C 1-6 heteroalkyls, substituted C 1-6 heteroalkyls, C 1-6 alkoxy, phenoxy and C 1-6 heteroalkoxy; n (m1) and (m2) are independently zero or one; n (n1), (n2), (p1), (p2) and (q) are independently zero or a positive integer; n Z is an electron withdrawing group; and n R 1 is a polymeric residue. which is optionally capped with a moiety of the formula: |