| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate |
2003-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76989969d54b114358c5398fa36a6f49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba951054a1dfff62e85f9e773d65e97a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adf5cd154653dda9408fd46682dd922e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13289c1c40899f9129d7c089c662b213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3cbbe354a77e8c6e2e367b08b9fa75e1 |
| publicationDate |
2004-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004053849-A1 |
| titleOfInvention |
Inhibitors of the E2F-1/cyclin interaction for cancer therapy |
| abstract |
The novel compounds of this invention have the general structural formula Ia-d: The compounds of this invention relate to 8-mer, 7-mer, 6-mer and 5-mer peptides having the following amino acid sequences, and referred to collectively as having “Formula Ia-d”: n Cap-AA8-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 8-mer Ia Cap-AA7-AA6-AA5-AA4*-AA3-AA2-AA1* 7-mer Ib Cap-AA6-AA5-AA4*-AA3-AA2-AA1* 6-mer Ic Cap-AA5-AA4*-AA3-AA2-AA1* 5-mer Id n n or a pharmaceutically acceptable salt or ester thereof, that inhibit the interaction of the transcription factor E2F-1 to Cyclin A. As an antagonist of the E2F-1/Cyclin A interaction, the compounds of the present invention may be used in the treatment of cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004176301-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11650687-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299513-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7449544-B2 |
| priorityDate |
2000-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |