| abstract |
A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable α-helix and has the following structure comprising at least 12 amino acids n R 1 -R 2 -A 1 -B 1 -(A 2 -B 2 -C 1 -A 3 ) m -(C 2 ) n -R 3 , wherein n A=an amino acid selected from the basic amino acids Lys,Arg or His n B=an amino acid selected from the aromatic amino acids Phe, Trp or Tyr n C=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, n Val or Ala, and n said peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-n of the repetitive sequence motifs (A 2 -B 2 -C 1 -A 3 ) have the retro orientation and the remaining repetitive motifs (A 2 -B 2 -C 1 -A 3 ) have the orientation as presented in the formula and wherein, n R 1 -R 2 - and R 3 are a number of amino acids, and wherein n m=1-10, preferably 2-8, more preferably 2-5 and n n=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock. |