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publicationDate 2004-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2004048258-A1
titleOfInvention Multiple-gene diagnostic probes and assay kits and method for the assessment of multiple markers for breast cancer prognosis
abstract The problem of inadequate broad-range prognostic factors for breast cancer is solved by providing a multi-gene probe for a single-step determination of disease outcome. The 5-genes chosen (HER2, Topo IIα, NM23-H1, CK19 and MMP9) are known to show altered expression in different breast tumors. The altered expression of any one of them has a similar prognostic significance, with respect to disease-free survival or overall survival. The multi-gene probe is labeled and used to screen a tumor specimen. The signal generated after the assay provides information that has prognostic significance. Since five prognostic markers are simultaneously assessed, a wider variety of breast cancers are covered and disease outcome prediction is improved in a wider population.
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