| abstract |
An autologous vaccine to tumor cells is produced by transducing the tumor cells with a herpes virus amplicon containing the gene for an immunomodulatory protein to provide transient expression of the immunomodulatory protein by the cells. The tumor cells may transduced with the herpes simplex amplicons ex vivo or in vivo. Suitable immunomodulatory proteins include cytokines, for example, interleukins, interferons, and chemokines such as RANTES, intercellular adhesion molecules, for example ICAM- 1 and costimulatory factors such as B 7.1. The tumor cells may also be transduced with one or more species of amplicon containing genes for two or more different immunomodulatory proteins. |