http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004038959-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2003-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e4f5d2291f662ec0f8f474f13b0d9ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1913af10a409f1f0ff84ded793a0e299 |
| publicationDate | 2004-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004038959-A1 |
| titleOfInvention | 3-Isoquinolinone derivatives as matrix metalloproteinase inhibitors |
| abstract | This invention provides compounds defined by Formula I n n n or a pharmaceutically acceptable salt thereof, n wherein R 1 , Q, R 2 , R 3 , R 4 , and n are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP-13 enzyme in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency, inflammatory bowel disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active component as described in the specification. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005004177-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9078888-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004142950-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267767-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010017048-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6894057-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002193377-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006247231-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9604931-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005085447-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9623021-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11524960-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6962922-B2 |
| priorityDate | 2002-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1271.