http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004038369-A1
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-54 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6427 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-76 |
filingDate | 2001-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ac27e10a045ad388ab2088e9b1f4838 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15dee9092ba97186078531917eb94567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9660b6a422d13ed47fd5ae1135e19ec2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bfdfb62c9a09149380cab28934b2e61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef98b786808c7d04e2eee90c84e49df3 |
publicationDate | 2004-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2004038369-A1 |
titleOfInvention | Airway-specific trypsin-like enzymes and method of using the same |
abstract | The subjects of the present invention are to provide a method of screening a compound or a polypeptide which inhibits the activity of AST, or inhibits PAR activation, mucus production promotion, cell proliferation, intracellular calcium influx or EGFR pathway activation due to AST, and further to provide a method of assaying AST in vivo and in biological cells or samples. n The present invention further includes the following inventions. ASTs whose each is protein comprising the whole amino acid sequence represented by SEQ ID NO: 1 or 2 or a part thereof or a mammalian AST protein having a 66% or more homology with the amino acid sequence represented by SEQ ID NO: 1 and in whose each a propeptide moiety is bound to a trypsin-like protein moiety via a disulfide bond. Nucleic acids encoding the same. Antibodies binding to the same. A method for assaying AST by using these antibodies. Further a method of assaying the inhibitory activity of a compound or a polypeptide to be assayed against AST or PAR activation, mucus production promotion, cell proliferation, intracellular calcium influx or EGFR pathway activation due to the AST. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005282253-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009137518-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006063930-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7867975-B2 |
priorityDate | 2000-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1094.