| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate |
2002-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e70c4209b795d679aba9b3cb43115d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06c1c7c1059223416461fab4c45c3425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afe95b7f2647d5b57ae7d5afdeb7bc50 |
| publicationDate |
2004-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004034211-A1 |
| titleOfInvention |
Mutation detection method |
| abstract |
The present invention is directed to improved methods for detection of mutations in DNA using Denaturing Matched Ion Polynucleotide Chromatography (DMIPC). The invention includes the following aspects: analysis of PCR amplification products to identify factors that affect PCR replication fidelity; design of PCR primers; selection of an optimal temperature for performing DMIPC; selection of the mobile phase composition for gradient elution; methods for column preparation and maintenance; and methods for preparing polynucleotide samples prior to chromatographic analysis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011100101-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267092-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009203022-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8640555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007190656-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010213063-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009098485-A1 |
| priorityDate |
1998-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |