| abstract |
Compounds having the general structure 11 are provided: n n n A is selected from the group consisting of C or CH and X and Y are independently selected from the group consisting of CH 2 , N, C═O, C═S, (CR 6 R 7 ) n , S═O, SO 2 , O, NR 9 , S, C(═O)—(CR 6 R 7 ) n , and C(═S)—(CR 6 R 7 ) n where n is 1, 2, or 3. W is selected from the group consisting of n n n and Z 1 , Z 2 , and Z 3 are independently selected from the group consisting of substituted carbon and nitrogen. L is selected from the group consisting of N, O, S, S═O, SO 2 , C(O), NC(O), NC(S), OC(O), OC(S), C(NR 10 ), C(NOR 10 ), and a covalent bond. Compounds of formula II are agonists of the melanocortin-4 receptor (“MC4-R”) and therefore may have useful properties for controlling diseases related to MC4-R action in humans, such as obesity and type II diabetes. |