http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004014984-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-42 |
| filingDate | 2001-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b354f96955c0ba6e5730e8e8727f070 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dddcfe22dc57d2996ec580fa8f409db3 |
| publicationDate | 2004-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004014984-A1 |
| titleOfInvention | Process for the preparation of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acid |
| abstract | Novel processes and intermediates are provided for the synthesis of derivatives of 4-amino-3-hydroxypyrrole-2-carboxylic acids that are useful as monomers for polyamides capable of binding dsDNA. According to one preferred reaction scheme, an alkyl alkoxymethylene nitroacetate (Formula VIII) is prepared by reaction of a trialkyl orthoformate or orthoacetate with a nitroacetate ester in the presence of a carboxylic anhydride. The compound of Formula VIII is condensed with an N-substituted glycine to yield an N-substituted (2-nitro-2-alkoxycarbonyl)vinyl glycinate ester (Formula VII). Ring closure in the presence of an alkali metal alkoxide yields a 4-nitro-3-hydroxypyrrole-2-carboxylic ester (Formula V). After blocking of the 3-hydroxy group to produce a further intermediate (Formula IV), the 4-nitro group is reduced to a 4-amino group (Formula III), and the 4-amino group is then blocked by reaction with a dicarbonate diester to produce the fully blocked intermediate (Formula II). Saponification of the 2-carboxylic acid ester yields a monomer having a free 2-carboxylic ester moiety (Formula I). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9986733-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10694739-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11510407-B2 |
| priorityDate | 2000-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 339.