| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_676b80da7ac92b84e447a83fb1630ae1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-18 |
| filingDate |
2002-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_881244ab0fe294e3b50c679b55eefe4e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbd57ee44b08707dfebf7e8a5724b36b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9af29e74e3529ba028ab644c2f3a7d73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b293d9bdea8b933b5564483fb5644ad0 |
| publicationDate |
2003-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003235811-A1 |
| titleOfInvention |
Crystallized mammalian carboxylesterase polypeptide and screening methods employing same |
| abstract |
Solved three-dimensional crystal structures of mammalian carboxylesterases (CEs) are disclosed. A solved three-dimensional crystal structure of a rabbit CE polypeptide co-crystallized with 4PP is disclosed. Solved three-dimensional structures of a human CE polypeptide co-crystallized with tacrine and a human CE polypeptide co-crystallized with homatropine are disclosed. The disclosed structures can be employed in the design of CE modulators. Methods of designing modulators of the biological activity of rabbit CE, human CE and other CE polypeptides, are also disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9068174-B2 |
| priorityDate |
2002-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |