| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
2003-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4b000add26f3bf32c5b76b851bf28de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c98b9d1a32502160d5f0dc6014f79094 |
| publicationDate |
2003-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003232782-A1 |
| titleOfInvention |
Method of controlling acetylation of metabolic enzymes |
| abstract |
A method for modulating the activity of an AMP-forming enzyme (AFE) is disclosed. The method is based upon the novel observation that the activity of these enzymes is controlled by acetylation of the enzymes to inactivate them and de-acetylation of the enzymes to re-activate them. The acetylation of the enzyme occurs at a characteristic lysine residue. Various polypeptides, nucleic acids and other molecules that are related to modulating the AFE activity are also disclosed. Further disclosed are methods of modulating cellular acetyl-CoA or propionyl-CoA levels in bacterial hosts, methods of identifying agents that can modulate the activity of AFE acetylases, and methods of identifying AFE mutants that are insensitive to acetylation regulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009053797-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023122805-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9241916-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846724-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8017634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11406709-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685937-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9597347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8242171-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016044219-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7977049-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014222459-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10648004-B2 |
| priorityDate |
2002-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |