http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003226161-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8243 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y203-0115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01H5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01H5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 |
| filingDate | 2002-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c128be9f83010d237ac2417d4276146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0975c9b6920d688d9b73081b7d3d16c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_068f35dc0424c7459f3eb7d1b4b8d5e2 |
| publicationDate | 2003-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2003226161-A1 |
| titleOfInvention | Salutaridinol 7-O-acetyltransferase and derivatives thereof |
| abstract | This invention provides a protein comprising consecutive amino acids, the amino acid sequence of which is illustrated in FIG. 8 (SEQ. ID No.14) or, a fragment thereof having at least 15 amino acids, or a variant thereof, the sequence of which has at least 70% identity with the amino acid sequence of FIG. 8 (SEQ. ID No.14) over a length of at least 400 amino acids. This invention further provides a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase protein of at least 6 consecutive amino acids which is not present in other plant acetyltransferases as illustrated in FIG. 2 (SEQ. IDs No.8 to 12). This invention further provides a nucleic acid molecule comprising consecutive nucleotides (i) the nucleic acid sequence of which is illustrated in FIG. 9 (SEQ. ID No.13) or FIG. 10 (SEQ. ID No.15), or (ii) a fragment thereof having a length of at least 45 nucleotides, or (iii) a variant thereof, the sequence of which has at least 70% identity with the sequence of FIG. 9 (SEQ. ID No.13) or FIG. 10 (SEQ. ID No.15) over a length of at least 1200 bases, or a sequence complementary to (i), (ii) or (iii), or the RNA equivalent of any of (i), (ii), or (iii). This invention further provides a nucleic acid molecule comprising a fragment of a salutaridinol 7-O-acetyltransferase gene, at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene and being chosen from the 5′ or 3′ untranslated regions of the sequence illustrated in FIG. 9 (SEQ. ID No.13), or a sequence which is complementary thereto. This invention further provides a method for producing pentacyclic morphinan alkaloids comprising (i) introducing a nucleic acid molecule encoding salutaridinol 7-O-acetyltransferase into a plant cell capable of expressing salutaridinol and/or salutaridine and/or (R)-reticuline, (ii) propagating said plant cell to produce a multiplicity of morphinan-producing cells, and (iii) recovering said morphinan(s) from said multiplicity of cells. This invention further provides a method for the production of thebaine comprising the steps of (i) contacting in vitro a protein having salutaridinol 7-O-acetyltransferase activity with salutaridinol and acetyl co-enzyme A at pH 8 to 9, and (ii) recovering the thebaine thus produced. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112789354-A |
| priorityDate | 2001-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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